Preparation, encapsulation and blood interaction studies of chemically and biologically synthesised magnetic liposomes


Abstract:
Magnetic liposomes are vesicles with encapsulated magnetic nanoparticles which can increase the bioavailability and targeting of a drug, and could be beneficial for many therapeutic purposes. The main objective behind this study was to conduct a comparative analysis on encapsulation and blood component interaction efficiency of liposomes with magnetic nanoparticles synthesised by biological and chemical methods. The overall results have shown a gradual increase in the yield of highly pure but toxic magnetic nanoparticles during chemical synthesis. Meanwhile, less toxic level and high encapsulation efficiency was found in the biologically synthesised nanoparticles and their liposomal formulation. The study visualises few parameters that stress the vitality of producing magnetic nanoparticles using biological method and encapsulating those nanoparticles in liposomes for wider usage in vivo.

Keywords:
Liposomes; Bioavailability; Haemotoxicity; Nanoparticles; Magnetic liposomes

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How to cite this article:
Baskar V & Karthick J. Preparation, encapsulation and blood interaction studies of chemically and biologically synthesised magnetic liposomes. Journal of Biological and Information Sciences. 2015. 4 (3). 9-15.
Available from: http://www.biolim.com/journals/BOJ001/001/BOJ001A0031.